I m concerned about how to proceed with endoscopy procedures after having had multiple negative reactions to sedation medications. Fentanyl makes me vomit nearly uncontrollably, Versed causes a paradoxical effect and a lingering, severe sense of profoundly disturbing effects on cognition that can last days afterward. Versed has also never caused any amnesia, on the contrary it does the opposite, causing an endless mental repetition of the most difficult or painful parts of the procedure that lasts for hours and is deeply disturbing. The best sedation experience I ever had was with Diazepam, but whenever I speak with a doctor about this they want to push Propofol instead. I don t understand this - it s repeatedly cited as great, but Propofol requires deeper sedation without any guarantee of the ability to communicate if pain is experienced, and it depresses people s pulse oximetry more than the benzo medications. From patient and nurse descriptions, Propofol seems to have been truly dangerous for the 25% of patients who have reactions to it. One nursing site said there is no way to reverse it and both the nurses sites and the patient sites consistently rate it high for side effects, especially for extremely painful, even frightening effects as it enters the body. It s clear that some people have a really good experience with it, but for those who don t, the experiences they describe are pretty horrific. Why is Propofol being touted as so good for everyone when nurses and patients don t rate it that way? Why is it so difficult to find a physician willing to use a bolus of Diazepam for a simple upper endoscopy procedure, when it used to be the norm? By chance would this a cost issue?