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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is A Positive ANA Test Result A Matter Of Concern?

Hi. I just got my bloodwork back. My wbc and rbc are fine. My hemoglobin is in range. I have no symptoms such as joint pain or anything else. I ve lost some hair, but this stems from recent stress and very poor diet. I tested positive for ANA 1:160 with a homogenous and speckled mixed pattern. Should I be worried?
Wed, 10 Aug 2016
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General & Family Physician,  's  Response
Anti-nuclear antibodies (ANA) are auto-antibodies directed against a variety of nuclear components. Most healthy people have low titer (
ANA presents different patterns depending upon staining of cell nucleus and can have a diagnostic value. Speckled and homogenous pattern is nonspecific. A nucleolar and centromere pattern is specific for scleroderma and CREST syndrome respectively. A positive ANA test does not always need to be repeated unless there is a strong suspicion of auto-immune disease. Titer between 1:200 and 1:300 require clinical assessment. Only if clinical assessment is positive for CTD then further testing is done. So need to worry as you do not any clinical symptom.
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Is A Positive ANA Test Result A Matter Of Concern?

Anti-nuclear antibodies (ANA) are auto-antibodies directed against a variety of nuclear components. Most healthy people have low titer ( ANA presents different patterns depending upon staining of cell nucleus and can have a diagnostic value. Speckled and homogenous pattern is nonspecific. A nucleolar and centromere pattern is specific for scleroderma and CREST syndrome respectively. A positive ANA test does not always need to be repeated unless there is a strong suspicion of auto-immune disease. Titer between 1:200 and 1:300 require clinical assessment. Only if clinical assessment is positive for CTD then further testing is done. So need to worry as you do not any clinical symptom. Thanks