I ve been on 100 mg of Losartan for about 6 years. I also have had signs of depression and wonder if this medication is a contributor. Sometimes I m ok, other times I m not. When feeling depressed I feel down in mood, I wake up during the night and hard to sleep. I also feel so down in my chest, like an ache, and feeling similar to having lost a loved one and want to cry. It is an awful feeling, I had that for several hours today but feeling somewhat better now. Can Losartan give me that kind of mood swing?