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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Joint Pain A Side Effect Of Pyzina Intake For Lungs Tb?

my mother is74 yrs old, taking treatment of lungs tuberculosis, being given 1250mg Pyzina 400mg Combutol and R CIN 450mg, she has acute joints pain in her right leg. Please tell whether it is side effects of any of the above drugs, if so, what should she take to cure this problem ?
posted on Fri, 14 Mar 2014
Twitter Mon, 20 Apr 2020 Answered on
Twitter Tue, 21 Apr 2020 Last reviewed on
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General & Family Physician,  's  Response
Hi,

Based on the history your mother seems to have developed gouty arthritis apparently caused by the medicines Pyzina and Combutol. After confirming the diagnosis she may be given a non-steroidal anti-inflammatory drug like indomethacin or naproxen.

Ask her to take plenty of oral fluids. A low steroid with tapering dose may be required for severe attacks. You do not need to discontinue Pyzina or Combutol.

Recurrent attacks may occur while taking these medicines, consider rheumatologic evaluation for acute gouty arthritis attacks and possible use of colchicine to prevent recurrent attacks.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr. Mohammed Taher Ali
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Is Joint Pain A Side Effect Of Pyzina Intake For Lungs Tb?

Hi, Based on the history your mother seems to have developed gouty arthritis apparently caused by the medicines Pyzina and Combutol. After confirming the diagnosis she may be given a non-steroidal anti-inflammatory drug like indomethacin or naproxen. Ask her to take plenty of oral fluids. A low steroid with tapering dose may be required for severe attacks. You do not need to discontinue Pyzina or Combutol. Recurrent attacks may occur while taking these medicines, consider rheumatologic evaluation for acute gouty arthritis attacks and possible use of colchicine to prevent recurrent attacks. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr. Mohammed Taher Ali