I think my question is basically answered below, though the answers don t quite agree. I was told to take omeprazole with ibuprofen, but the directions on the omeprazole box say take each morning before eating. i am not taking because of stomach issues but because doctor said to take with ibuprofen, which i won t even take everyday. Makes sense to me to take the antacid before or with the meal and the ibuprofen after, when needed. But I would take two ibuprofen over the day (breakfast and dinner), but only one omeprazole daily, correct?