Hello, No medication is advisable for prolonged use as they have side effects that may not be good for health. It looks like your wife is having irregular menstruation & menorrhagia(heavy bleeding) if she stops the medications. She needs to be investigated by a gynae. Get her blood tests & USG uterus done to detect any polyps or fibroid that may cause such discomforts. If reports are positive, get her treated at the earliest. Such symptoms may arise due to hormonal imbalance which needs correction. She can take Regesteron (5mg) after consultation with a gynae along with a vitamin B complex. Let her stay away from anxiety & stress. Her treatment will depend upon the pathology detected. She should take food rich in calcium, protein & green leafy vegetables. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Nupur K, General & Family Physician