Hello. Welcome to HCM and thank you for your question. I carefully read your query. Well, as you are aware of, they both are from the same class of drugs (angiontensiogen converting enzyme inhibitors). The effects of these drugs, are a class-effect, which means all the benefits and side effects are dedicated almost equally to every member of this family of drugs. In fact, there are some studies that prefer the usage of always innovative agents, and let the old agents aside. My opinion is that this is not indicative that a more expensive drug should be used, at all costs. In developing countries, such as mine, cost-effectiveness is always an issue, and we receive great results even when we use the older drugs. As I said, this is a class-effect and it is totally safe to switch from one ACE-I to another, and also effective. Of course, bare in mind, that all the ACE-I have the side effect of dry cough, which can happen up to 15% of people using them. In that case, I recommend you to switch to angiotensin receptor blocker (ARB: the sartans ). I hope I was helpful with my answer. Good day. Dr. Meriton