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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Taking Dextromethorphan And Guaifenesin Along With Amitriptyline Be Safe?

Hell, yes, I take 75 m of amitriptyline a day, I have recently been having a cough, so I purchased and took a cough medicine with dextromethorphan, guaifenesin, and phenylephrine, do I need to worry about a bad reaction?, didnt see the warning about some anti depressants until after I too 20 ml.
posted on Thu, 22 Oct 2015
Twitter Sun, 22 Nov 2015 Answered on
Twitter Mon, 23 Nov 2015 Last reviewed on
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OBGYN, Maternal and Fetal Medicine,  's  Response
Welcome to HealthCareMagic. Your query has been assigned to me and I am happy to assist you today for the health issues you raised.


No it is not safe to mix Amitryptyline + Dextromethorphine as they are the drugs which increase the levels of Serotonin in brain. I have seen many patients with serious pharmacological interaction in patients and sometimes it has also caused life-threatening interaction in patients. I usually do not prescribe them both to be taken at the same time. You should avoid taking them before consulting a local Physician or your treating Doctor.

Hope it was all you needed the answer for. If you have some more questions or doubts in mind, please let us know to help you. We are all a team of best experts from all over the world to assist patients online. Give your feedback to help us make this service even better.

Healthiest Regards!
Dr. Sumaira Kousar MD.
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Is Taking Dextromethorphan And Guaifenesin Along With Amitriptyline Be Safe?

Welcome to HealthCareMagic. Your query has been assigned to me and I am happy to assist you today for the health issues you raised. No it is not safe to mix Amitryptyline + Dextromethorphine as they are the drugs which increase the levels of Serotonin in brain. I have seen many patients with serious pharmacological interaction in patients and sometimes it has also caused life-threatening interaction in patients. I usually do not prescribe them both to be taken at the same time. You should avoid taking them before consulting a local Physician or your treating Doctor. Hope it was all you needed the answer for. If you have some more questions or doubts in mind, please let us know to help you. We are all a team of best experts from all over the world to assist patients online. Give your feedback to help us make this service even better. Healthiest Regards! Dr. Sumaira Kousar MD.