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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is There Another Drug That Can Be Used To Treat A-fib And V-tach Without As Severe Side Effect?

I have just recently been put on Amiodarone 200mg for Afib and Vtach, How many people have died using this drug for long term? Other than Amiodarone and Metoprolol is there another drug that can be used to treat Afib and Vtach without as severe side effects such as the Amiodorone?
Tue, 9 Jun 2015
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Cardiologist 's  Response

Hello!

Thank you for asknig on HCM!

Regarding your concern, I would explain that Amiodaron is one of the most effective antiarrhythmics used for the above mentioned purpose. But, its pharmacokinetic and pharmacodynamic profile may lead t oserious drug depositions in several organs (liver, cornea, lungs, skin, etc) and may lead to serious complications, such as pulmonary fibrosis, liver toxicity, vision disturbances, dangerous prolongation of QT interval on ECG, dysthyroidism, etc.

The best therapeutical strategy for treating your arrhythmias would be to avoid antiarrhythmics (as they may paradoxically show proarrhythmic effects too), and try to eleminate the possible myocardial organic substrate of arrhythmia by possible cardiac ablation, if suchj a procedure is available to your attending medical center. A comprehensive electrophysiological study should be performed first, to address the pathological issues.

Ather medical options are avaliable, besides Amiodaron, such as other antiarrhythmics like sotalol, propafenone, flecainide, etc, but each othem has its own side effects.

Hope to have been helpful! Greetings! Dr. Iliri



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Is There Another Drug That Can Be Used To Treat A-fib And V-tach Without As Severe Side Effect?

Hello! Thank you for asknig on HCM! Regarding your concern, I would explain that Amiodaron is one of the most effective antiarrhythmics used for the above mentioned purpose. But, its pharmacokinetic and pharmacodynamic profile may lead t oserious drug depositions in several organs (liver, cornea, lungs, skin, etc) and may lead to serious complications, such as pulmonary fibrosis, liver toxicity, vision disturbances, dangerous prolongation of QT interval on ECG, dysthyroidism, etc. The best therapeutical strategy for treating your arrhythmias would be to avoid antiarrhythmics (as they may paradoxically show proarrhythmic effects too), and try to eleminate the possible myocardial organic substrate of arrhythmia by possible cardiac ablation, if suchj a procedure is available to your attending medical center. A comprehensive electrophysiological study should be performed first, to address the pathological issues. Ather medical options are avaliable, besides Amiodaron, such as other antiarrhythmics like sotalol, propafenone, flecainide, etc, but each othem has its own side effects. Hope to have been helpful! Greetings! Dr. Iliri