My friend of 43 years had kidney failure 1 1/2 yrs. ago and is now on dialysis, due to many years of neglecting high blood pressure and taking 12 to 20 Iburprofin per day for many years. I have noticed that her thinking does not seem right. That there seems to be something going on in the brain. It's like she has lost her good sense. Is this due to the kidney failure and build-up of toxins.