Hi ! I am Dr Shareef answering your query. I am not aware for what condition you took such dosage of
acetaminophen. This kind of dosage may cause irritation of the gastric and duodenal mucosa giving rise to duodenitis/
gastritis giving rise to such pain. This pain will increase in empty stomach due to non dilution of the acid produced in the stomach and reaching the
duodenum. This may be the reason for increased pain in empty stomach when you do not eat and awakening you in nights.
Also large doses of acetaminophen may give rise to some kind of hepatic derangements, and if associated with inflammation of the
liver, may cause such symptoms.
Under these circumstances, if I would have been your doctor, I would advise you not to skip your food any time of the day and night, avoid alcoholic and aerated beverages if you do take, avoid fatty and fried spicy food. Also raising the head end of the bed by one or two blocks helps the acid to pass through the duodenum faster, and thus may help in relieving your symptome. Also change in life style like regular exercises and regular routine eating habits instead of
binge eating may also help you in this.
On the medicinal side, I would advise you to take
proton pump inhibitor with a prokinetic drug and a
probiotic for a prolonged duration. As these are prescription drugs, you have to get yourself examined by a doctor to get the essential prescription.
If these measures are not helping you out, then I would go for some routine tests along with a liver function test, and also consider referring you to a gastro-enterologist for an endoscopic examination of your stomach and doudenum. By the way, you have not mentioned the report of your endoscopic examination.
I hope these information will help you out. Wishing you an early recovery. Thanks and good luck.