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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Right Dose For Prophylaxis Enoxaparin For DVT Patient Of 28kg With CrCl Of 54ml/min?

I am a student working on my assignment, Thanks
I want to know the right dose of prophylaxis Enoxaparin for DVT patient of 80kg with CrCl of 54ml/min?
I want to know the right dose of prophylaxis Enoxaparin for DVT patient of 28kg with CrCl of 54ml/min?
I want to know the right dose of treatment Enoxaparin for DVT patient of 80kg with CrCl of 60ml/min?
I want to know the right dose of treatment Enoxaparin for DVT patient of 80kg with CrCl of 19ml/min?
Fri, 5 Jul 2013
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General & Family Physician 's  Response
Hi,

Dose for Inpatient treatment of acute DVT with or without pulmonary embolism is 1 mg/kg SC every 12 hours or 1.5 mg/kg SC once daily (with warfarin) up to 17 days.
Dose for Outpatient treatment of acute DVT without pulmonary embolism is 1 mg/kg SC every 12 hours (with warfarin) up to 17 days

In patients with renal impairment, there is an increase in exposure of enoxaparin sodium. All such patients should be observed carefully for signs and symptoms of bleeding. No dosage adjustment is recommended in patients with mild (creatinine clearance 50-80 mL/min) and moderate (creatinine clearance 30-50 mL/min) renal impairment. Because exposure of enoxaparin sodium is significantly increased in patients with severe renal impairment (creatinine clearance
Dosage Regimens for Patients with Severe Renal Impairment (creatinine clearance Dose for Inpatient treatment of acute deep vein thrombosis with or without pulmonary embolism, when administered in conjunction with warfarin sodium is 1 mg/kg administered SC once daily
Outpatient treatment of acute deep vein thrombosis without pulmonary embolism, when administered in conjunction with warfarin sodium is 1 mg/kg administered SC once daily

In patients with renal failure, treatment with enoxaparin has been associated with the development of hyperkalemia.

Hope that answers your query.

All the best for your assignment

Regards
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Right Dose For Prophylaxis Enoxaparin For DVT Patient Of 28kg With CrCl Of 54ml/min?

Hi, Dose for Inpatient treatment of acute DVT with or without pulmonary embolism is 1 mg/kg SC every 12 hours or 1.5 mg/kg SC once daily (with warfarin) up to 17 days. Dose for Outpatient treatment of acute DVT without pulmonary embolism is 1 mg/kg SC every 12 hours (with warfarin) up to 17 days In patients with renal impairment, there is an increase in exposure of enoxaparin sodium. All such patients should be observed carefully for signs and symptoms of bleeding. No dosage adjustment is recommended in patients with mild (creatinine clearance 50-80 mL/min) and moderate (creatinine clearance 30-50 mL/min) renal impairment. Because exposure of enoxaparin sodium is significantly increased in patients with severe renal impairment (creatinine clearance Dosage Regimens for Patients with Severe Renal Impairment (creatinine clearance Dose for Inpatient treatment of acute deep vein thrombosis with or without pulmonary embolism, when administered in conjunction with warfarin sodium is 1 mg/kg administered SC once daily Outpatient treatment of acute deep vein thrombosis without pulmonary embolism, when administered in conjunction with warfarin sodium is 1 mg/kg administered SC once daily In patients with renal failure, treatment with enoxaparin has been associated with the development of hyperkalemia. Hope that answers your query. All the best for your assignment Regards