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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Side Effects Like Sleep Talking, Pain In Hands And Feet After Increasing Methotrexate To 15mg. Advice?

I have been taking methotrexate for 4 years to help treat periphereal vasculitic neuropathy. I took 15mg per week for the first 3 years and then the dosage was reduced to 10mg per week. One month ago, my dosage was increased back to 15mg per week and I am experiencing strange side effects that I don't remember having in the past. For instance, when I go to sleep, I am having this half awake and half asleep feeling. I talk while in this state and have been having anger issues at night due to a feeling of desperosity for help with the pain in my hands and feet. I am driving my husband crazy with the sleep talking. My husband tries to help me but I feel so angry while I'm half asleep although, according to him, I seem awake. I have no history of mental illness. I don't know what to do. I simply cannot help myself at night.
Tue, 4 Jun 2013
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Internal Medicine Specialist 's  Response
Hi
Long term oral use of Methotraxate may cause Neurotoxicity leading to confusion, tremor, ataxia, irritability, and somnolence and Progressive dementia and leukoencephalopathy. You better change it in cosultation with your Doctor.
Regards
Ranjit
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Side Effects Like Sleep Talking, Pain In Hands And Feet After Increasing Methotrexate To 15mg. Advice?

Hi Long term oral use of Methotraxate may cause Neurotoxicity leading to confusion, tremor, ataxia, irritability, and somnolence and Progressive dementia and leukoencephalopathy. You better change it in cosultation with your Doctor. Regards Ranjit