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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Alternative For Minivelle.75

I had a complete hysterectomy 15 years ago and after going through some really weird side effects of ert I ended up taking 1mg of estradiol for all of these years. Seemed to be fine until a few years ago and extreme night sweats began (3-4 a night) which has caused a major inability to sleep through the night. I literally wake every 2 hours but am able to go back to sleep. My MD had suggested I decrease my estradiol because of my age 56 so I varied between .5-1mg. Recently, he switched me to the minivelle .75-.5mg trying to figure out which dose is right for me. The .75 causes painful breasts and the .5 does nothing much. I am EXHAUSTED all the time and my GERD is acting up again which it did when I first began ERT. My GERD is a weird kind where I rarely have reflex. Instead it affects my bronchioles. I m beyond frustrated as I am a very active and energetic person. I just want to sleep and have good energy. I m not overweight and I exercise. Thank you for any help you might be able to give me.
Wed, 28 Sep 2016
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Diabetologist,  's  Response
Hi
I would have suggested my patient to begin on paroxetine 7.5mg (Brisdelle) for the vasomotor symptoms (increased sweating).
Now regarding continuation of Minivelle, I would be cautious and wouldn’t stop it altogether. You are already on HRT since 15 years and I would not like it to stop abruptly. I would advice to continue Minivelle 0.5mg and slowly taper over months if required.
I can understand your concern about GERD. I would have prescribed a proton pump inhibitor like pantoprazole 40mg once daily before food. Apart from medications, I would advice lifestyle modifications for GERD like avoiding sleeping on right side, strict diet with taking servings at regular intervals, reducing stress.
Hope the above information helps you in your discussion with your MD. Thanks.
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Suggest Alternative For Minivelle.75

Hi I would have suggested my patient to begin on paroxetine 7.5mg (Brisdelle) for the vasomotor symptoms (increased sweating). Now regarding continuation of Minivelle, I would be cautious and wouldn’t stop it altogether. You are already on HRT since 15 years and I would not like it to stop abruptly. I would advice to continue Minivelle 0.5mg and slowly taper over months if required. I can understand your concern about GERD. I would have prescribed a proton pump inhibitor like pantoprazole 40mg once daily before food. Apart from medications, I would advice lifestyle modifications for GERD like avoiding sleeping on right side, strict diet with taking servings at regular intervals, reducing stress. Hope the above information helps you in your discussion with your MD. Thanks.