With MS there will be degeneration in protecting layer of spinal cord and brain. Because of this the signals between brain and body is not interpreted properly. And due to this there are various symptoms like fatigue, bowel and bladder problem, tingling and numbness, vision problem, depression, pain in body, itching, headache , seizure etc is possible. Here you have ask specific for treantnet of pain: There are various drugs like Non-steroidal anti-inflammatory drugs (also known as NSAIDS) such as aspirin, ibuprofen (Motrin, Advil) and naproxen (Aleve) are most commonly used to treat musculoskeletal pain. Other common over the counter treatments are pain relievers such as Tylenol (Acetaminophen), which may produce fewer stomach side effects. Other than this there are some more medication: Anticonvulsants (also known as snti-seizure medications) are the major category of medications prescribed for pain in MS, and are used to treat neuropathic pain. Antidepressants are used to treat neuropathic pain and depression. Antidepressants that selectively inhibit the reuptake of serotonin are called SSRIs are those that inhibit the reuptake of both norepinephrine and serotonin and called SNRIs. There is evidence that the SNRIs Duloxetine and Venlafaxine are effective in the treatment of neuropathic pain but there is less evidence of the effectiveness of SSRIs. Narcotics (opioids) such as morphine, codeine, hydrocodone and oxycodone are sometimes used to treat neuropathic, acute tissue injury and musculoskeletal pain. There is evidence that opioids reduce neuropathic pain, but research on their effectiveness in MS is limited. Long-term use of opiods can result in tolerance and/or increased pain sensitivity in some people, so it is important to discuss these risks and other possible side effects with your health care provider. Muscle relaxants and anti-spasticity medications are sometimes used to treat spasm-related and musculoskeletal pain. Medical marijuana (also known as cannabinoids) There is some evidence that cannabinoids reduce central neuropathic pain and spasticity in people with MS and more research is underway. All medications have possible side effects, some of which can be serious. Discuss all side effects with your provider. Apart from this doing regular exercise and physiotherapy treatment with healthy habits and lifestyle will also help you to reduce disease progression. Take care