hi. noted history of gallstones with intake of medications. in early stages of gallstone formation, it is possible for the sludges or smaller stones to dissolve with the medication intake. but if it s already big and is numerous, the chance for it to dissolve is less, causing the symptoms to ensue despite medication intake. if the symptoms are bothersome, persistent, or increasing in frequency of occurrence, it is best to consult with a doctor with urgency, preferably a general surgeon, for physical examination and clinical evaluation. diagnostics (such as ultrasound, blood count, liver function tests, etc.) and management (medical and surgical) will be directed accordingly. cholecystectomy (surgical removal of the gallbladder) is the definitive treatment, which could be done laparoscopically (goldstandard) or thru open technique. low fat diet is also recommended. hope this helps. good day!! ~dr.kaye