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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For HCV After Relapse

Hi my wife is 50 year old and diagnosed HCV positive ( GENO TYPE 3).and infected chronically trough blood transfusion 23 years ago. She was treated for 6 months with Pegylated interferon & Ribavarin. Virus disappeared during the treatment bur reappeared within 1 month after stopping treatment .The liver is showing moderate hepatomegaly and fatty changes.What is the current line of treatment, we can give?
Mon, 2 Nov 2015
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Infectious Diseases Specialist,  's  Response
Hi,

Welcome to HCM.

I understand your concern about HCV infection, but unfortunately HCV infection of genotype 3 is most resistant to treatment with bad prognosis. Newer drugs are available like simeprevir plus sofosbuvir but these are most effective in genotype 1 HCV. The effectiveness of the treatment depends on the following factors:
1. Age of patient
2. Presence of cirrhosis
3. Viral load of HCV.
I suggest you discuss with her treating doctor combination therapy of pegylated interferon and ribavarin with increased dose as that is the best therapy for genotype 3 HCV keeping the above mentioned criteria in mind.
Thanks.
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Suggest Treatment For HCV After Relapse

Hi, Welcome to HCM. I understand your concern about HCV infection, but unfortunately HCV infection of genotype 3 is most resistant to treatment with bad prognosis. Newer drugs are available like simeprevir plus sofosbuvir but these are most effective in genotype 1 HCV. The effectiveness of the treatment depends on the following factors: 1. Age of patient 2. Presence of cirrhosis 3. Viral load of HCV. I suggest you discuss with her treating doctor combination therapy of pegylated interferon and ribavarin with increased dose as that is the best therapy for genotype 3 HCV keeping the above mentioned criteria in mind. Thanks.