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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Castleman S Disease

In July my husband went to the doctor concerning an enlarged inguinal lymph node. After taking an in depth history the doctor rushed him for a colonoscopy fearing colon cancer. It was, we were also informed that Lynch Syndrome was the cause. They started planning a subtotal colectomy and determining what treatments he would have. After attempting the operation they found a large amount of inflammation sticking to his bladder and prostate. They started him on pre-op FOLFOX to shrink the tumor so they can remove it. Meanwhile, we heard nothing concerning the node, only that it wasn t related to the Colon Cancer. They removed the node and said it looked clean, a week later they told us that it wasn t. They found a sarcoma in the node during biopsy. That was the first time we herd the word Castleman s. Over the period of a month it was bounced around. It could be, it probably isn t, it looks like it, it s so rare it s doubtful.... Now even his oncologist is referring to it as Castleman s Disease. They are still steadily treating the Colon Cancer (for which I m grateful), but not doing much concerning this. The did a PET scan and found that the other nodes in his right inguinal region are also swollen and said it would be something to discuss after he has his resection and post-operative chemo. Don t get me wrong, I know we have to treat the Colon Cancer, but if you walked into a room and saw a gray tabby cat and a purple spotted tiger, wouldn t you at least pay a little attention to the tiger? What is known about this disease?
Fri, 8 May 2020
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Orthopaedic Surgeon 's  Response
Hi,

It appears like a case of multi-centric chemotherapy. Treatment strategy may include radiotherapy, immuno-therapy, anti-viral agents and monoclonal antibodies against il-6.

Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Rohan Shanker Tiwari, Orthopedic Surgeon
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Suggest Treatment For Castleman S Disease

Hi, It appears like a case of multi-centric chemotherapy. Treatment strategy may include radiotherapy, immuno-therapy, anti-viral agents and monoclonal antibodies against il-6. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Rohan Shanker Tiwari, Orthopedic Surgeon