Dear Doctor, I am a 39 yr old single male. Suffered from chronic fatigue syndrome 8 yrs ago. My doctor has put me on anti-depressants and supplements since then. I am having Mirtaz dosage between 15 to 30mg. Mirtaz makes me drowsy through the day irritable, angry and severe constipation. Last year my father passed away & gradually my health deteriorated. Leading to muscle spasms. My doctor advised me to change Mirtaz to Nexito 5 mg in the morning 5mg at night. After consuming it for 2 days I couldnt sleep through the night, feeling great degree of lethargy through the day hence switched to Mirtaz. My questions I have terrible sugar cravings Sensitive to cold temprature Anger, irritable, sluggish, constipation Excess urination Headaches Slow memory My job is to travel around the world due to which i have to adjust to diff clocks Constant pain in mid back & shoulder Sensitive to authority Should I consume Mirtaz? Or have Nexito? Or both Plse suggest Thanks & regards