I take numerous medications for osteoarthritis, fibro, connective tissue disease & have headaches every afternoon that seem to start on my way home from work. I work 8-noon. I m a laryngectomee with gastric pullup. I take Roxicet, Gabapentin, Prednisone, Clexa, Prilosec (bleeding ulcer), Fiorcet, Zofran, Calcitrol, Lodine XL & Plaquenil plus Magox, B-12 & alot of Calcium. I can t seem to get over these headaches. It started in 2005 as once in awhile & now is an everyday thing. I ve just had my eye s tested & they did the Plaquenil test too & I m just fine on that account. I take all those meds daily. I know it s alot. :(