respected Ashok sawant, hi I evaluated your query thoroughly. *Primary concern is whether she is having primary or secondary vasculopathy? not mentioned by you which is very vital. *In abscence of that I would suggest : @ Keep her BP , Blood sugar, Cholesterol levels, body weight under control. @ Life style modifications including - Less intake of salt as possible. - diet should contain enough proteins, vitamins, minerals, iron. - avoid smoking / alcohol / abuse substances if any - if using should avoid birth control pills - moderately light exercises at home - meditations and YOGA for boosting overall immunity & build the spirit - avoid injury to lower limb - keep ambulatory till possible @ In our clinic , we prescribe antibiotics according to Pus culture sensitivity along with care of local wound. Hope this clears your query. Thanks for using Health Care Magic & keeping trust in our medical services. Wishing your sister in law happy healthy life ahead. Regards Bye take care, would love to assist in any further health related queries in future Dear.