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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Taking Glimipride And Metformin For Diabetes. No Change In Sugar Level After Taking Repaglinide. Why?

my mother around 60 years is diabetic & was on with 4mg of glimipride & 1000mg of metformin daily. Her FBS was 210, PPBS 450. Now she was changed to repaglinide 2mg before every meals and with 1000mg of metformin daily. 500mg in the morning & 500mg in the night. But her sugar levels are still the same. is their a requirement of increasing the dose of repaglinide. Kindly suggest
Sat, 30 Mar 2013
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General & Family Physician,  's  Response
Hello,
I think probably your mother is having beta cell burnout of pancreas,which is a normal occurrence in long standing diabetics.When such a situation arises,no matter whatever dose of sulfonylurea ureas you give,it is not going to increase the insulin production from the pancreas.
I think she is in need of injectable insulin since her blood sugar levels are very high.
However you may consult a diabetologist and get your mother thoroughly evaluated.
He might try some newer anti diabeticsehich may help your mother but in the end,injection insulin would be the right choice for your mother.
Discuss with your doctor about it and kindly don't increase the dose or change any medicine of your own.
Thanks

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Taking Glimipride And Metformin For Diabetes. No Change In Sugar Level After Taking Repaglinide. Why?

Hello, I think probably your mother is having beta cell burnout of pancreas,which is a normal occurrence in long standing diabetics.When such a situation arises,no matter whatever dose of sulfonylurea ureas you give,it is not going to increase the insulin production from the pancreas. I think she is in need of injectable insulin since her blood sugar levels are very high. However you may consult a diabetologist and get your mother thoroughly evaluated. He might try some newer anti diabeticsehich may help your mother but in the end,injection insulin would be the right choice for your mother. Discuss with your doctor about it and kindly don t increase the dose or change any medicine of your own. Thanks