Hi there, Thanks for your query. * Firstly, thyroid nodules is called Multi-nodular goiter, which usually produces Thyroid hormone in excess quantities (condition called Hyperthyroidism). * Sometimes, inflammation of thyroid glands occurs (called Thyroiditis- which is of different types, depending on the cause). This frequently causes compression over the throat, resulting in difficulty in swallowing but no pain. * Pain in throat, difficulty in swallowing and sore sensation is due to inflammation (bacterial infection) of the throat. A 5-7 days course of suitable antibiotics, anti-inflammatory pain-killers, such as ibuprofen + paracetamol combination and saline gargles (with 4 spoons of salt in a glass of hot water) 3-4 times a day, will cure the infection. VICODIN will NOT be of great help. * At the same time, get your Thyroid hormone levels estimation done to confirm/rule out overactive thyroids, before it progresses. Consult your doctor and apprise him of my opinion. I am certain that he agree with me, order required tests, and- based on the reports- will prescribe suitable treatment as advised. Please revert back to me (through DIRECT QUERY, addressed to me personally) for further queries/clarifications, if any. If you find my response helpful and informative, do not forget an “excellent” (5-star rating) to my answer, to ENCOURAGE all doctors- engaged in social service- to render sound advice to the FREE queries. Fond regards and have a nice day Dr. Rakesh Karanwal