Hello, Thanks for your query. Strone is PROGESTERONE, what your wife is feeling is side-effects of progesterone. If she misses her periods get a urine pregnancy test done. Side -effeccts of progesterone: Stop using this medication and call your doctor at once if you have any of these serious side effects: sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance; fast or pounding heartbeats; chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; unusual or unexpected vaginal bleeding; migraine headache; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); swelling in your hands, ankles, or feet; fever, chills, body aches, flu symptoms; a breast lump; or symptoms of depression (sleep problems, weakness, mood changes). Less serious side effects of progesterone may include: mild nausea, diarrhea, bloating, stomach cramps; dizziness, spinning sensation; hot flashes; mild headache; joint pain; breast pain or tenderness; cough; acne or increased hair growth; changes in weight; or vaginal itching, dryness, or discharge. Less serious side effects of progesterone may include: mild nausea, diarrhea, bloating, stomach cramps; dizziness, spinning sensation; hot flashes; mild headache; joint pain; breast pain or tenderness; cough; acne or increased hair growth; changes in weight; or vaginal itching, dryness, or discharge. I hope this information has been both informative and helpful for you. In case of any doubt, I will be available for follow ups. Wish you good health. Regards, Dr Arif You can consult me again directly through my profile http://www.healthcaremagic.com/doctors/dr-arif-n-khan/65133