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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Was Taking Diclofenac For Spondylitis, Now Stopped And Level Raised. How To Get Normal Level?

good day

i've been taking diclofenac for my ankylosing spondylitis for over ten months now, average of 30-50 mg per day. i recently have remission and stopped taking diclofenac, but when i visited the clinic today for sgpt and creatinine test i have 88 and 1.1 respectively. i don't feel anything bad, nor have yellowish skin and other liver problem symptoms but my sgpt really raised from just 40 before i medicated with diclofenac. will my sgpt return to normal level soon? what can i do for now?
Fri, 18 Oct 2013
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Internal Medicine Specialist 's  Response
Hi there,

Thanks for your query.

* The elevation of SGPT is or MINOR concern (it is just temporary): it is apparently due to diclofenac or any other medicine (such as Sulfasalazine) that you are on. The SGPT levels return to normal range within 4-8 weeks after stopping the offending drug. You NEED NOT do anything for it.

* I would advise you against taking regular pain-killers as they tend to harm the kidneys (called Analgesic nephropathy), apart from water retention in the body and stomach ulcers. Instead, you should switch over to Sulfasalazine as described below.

* Serum Creatinine too is within normal range. Please refer to the normal range given in your report, since each kit (used for carrying out this test) has different Normal Ranges.

* Lastly, I would recommend use of regular Sulfasalazine (up to 3 grams daily if you continue to have problems.) It is quite effective in controlling your spondylitic symptoms and, would therefore, reduce your dependence on pain-killers.

Consult your doctor who knows what would be best for you.

Dr. Rakesh Karanwal
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General & Family Physician Dr. Chobufo Ditah's  Response
Hi and thank you so much for this query.

I am so sorry to hear about this ankylosing spondylitis and the pains it has caused you. It is not uncommon for patiemts to see soe changes in their liver enzymes and renal tests after using diclofenac for long. This is the case with you. The good news is that it cannot get any worse than it is right now and more so because you have stopped the drugs. Ever other day moving forward represents a day of no ore aggression to theses organs and a progressive recovery from the effects of the drugs. Exactly how long is not possible right now but it may take up to 3-6months for all to settle back to normal. For now, stopping the drugs is ideal as you have already done. Avoid taking any drugs unless otherwise not possible to do without or clearly has no effects on the kidneys or liver. Always ask a doctor or pharmacist and only accept after they must have taken these findings into consideration before prescription.

I hope this helps. I wish you well. Feel free to use our services as the need does arises. Cheers!
Dr. Ditah, MD
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Was Taking Diclofenac For Spondylitis, Now Stopped And Level Raised. How To Get Normal Level?

Hi there, Thanks for your query. * The elevation of SGPT is or MINOR concern (it is just temporary): it is apparently due to diclofenac or any other medicine (such as Sulfasalazine) that you are on. The SGPT levels return to normal range within 4-8 weeks after stopping the offending drug. You NEED NOT do anything for it. * I would advise you against taking regular pain-killers as they tend to harm the kidneys (called Analgesic nephropathy), apart from water retention in the body and stomach ulcers. Instead, you should switch over to Sulfasalazine as described below. * Serum Creatinine too is within normal range. Please refer to the normal range given in your report, since each kit (used for carrying out this test) has different Normal Ranges. * Lastly, I would recommend use of regular Sulfasalazine (up to 3 grams daily if you continue to have problems.) It is quite effective in controlling your spondylitic symptoms and, would therefore, reduce your dependence on pain-killers. Consult your doctor who knows what would be best for you. Dr. Rakesh Karanwal