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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Chances Of Leukaemia In Progeny From Mother With Lymphoblastic Leukaemia?

I m Acute lymphoblastic leukaemia patient had chemotherapy in 2001 from Rashid hospital in Dubai when my age was 14 today I’m 25 actually i have a question at the moment I’m unmarried and if in future I’m planning to get married means in my blood relation to my first or second cousin will my disease will affect my wife or my children. Respectful doctors I need best suggestion from you I will really appreciate….. Matloob Muhammad Aslam
Fri, 20 Mar 2015
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Radiologist,  's  Response
Hi,
Thanks for writing in.

Leukemia in the mother can rarely be transmitted to progeny but more research is required. There is a gene known as the BCR-ABL fusion gene, or the Philadelphia chromosome which if present in the mother’s cancer cells can cross over to the baby. This is not fully understood.

If the patient of leukemia is the father then the sperm DNA is not affected by the leukemia to cause the disease in next generation. However, as he might have got chemotherapy or radiation therapy at that time then it will help to get a semen analysis done to know if there is any condition like sub normal fertility due to cancer treatment.

Fertility impairments among men treated during childhood for cancer are known to occur after some, but not all, types of anti-cancer therapy. Majority of survivors show no evidence of fertility impairment after cancer treatment of leukemia. However, men treated at a young age with high dose head radiation therapy may have impaired fertility.
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What Are The Chances Of Leukaemia In Progeny From Mother With Lymphoblastic Leukaemia?

Hi, Thanks for writing in. Leukemia in the mother can rarely be transmitted to progeny but more research is required. There is a gene known as the BCR-ABL fusion gene, or the Philadelphia chromosome which if present in the mother’s cancer cells can cross over to the baby. This is not fully understood. If the patient of leukemia is the father then the sperm DNA is not affected by the leukemia to cause the disease in next generation. However, as he might have got chemotherapy or radiation therapy at that time then it will help to get a semen analysis done to know if there is any condition like sub normal fertility due to cancer treatment. Fertility impairments among men treated during childhood for cancer are known to occur after some, but not all, types of anti-cancer therapy. Majority of survivors show no evidence of fertility impairment after cancer treatment of leukemia. However, men treated at a young age with high dose head radiation therapy may have impaired fertility.