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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Long Term Effects Of Hydrocodone After Knee Replacement?

my husband had both knees replace last fall in the process he has been taking hydrocodone for 2 years for pain, he was supposed to be off that medication but is obviously addicted to it and his doctor keeps giving it to him? What are the long term effects of this?
Thu, 4 Sep 2014
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Addiction Medicine Specialist 's  Response
About what you've seen.
The hydrocodone has little/no effect on vital organs. Usually it also contains tylenol which in overdose can be damaging to the liver (takes the equivalent of FOUR extrastrength tylenol 4000 mg At One Time to be possibly toxic. We've all taken much more than that amount over our lifetime.. it has to be an overdose).

Likewise death from hydrocodone has to be an overdose and that would have to be more than 5 tablets in one handfill at a very minimum (and at that level likely requires a lot of alcohol or other sedatives to be fatal).
And....
Tolerance....getting used to the medicine and not having it work as well (NOT equivalent to addiction).
Withdrawal... diarrhea/sweats/shakes with stopping suddenly (likely requires 100 mg a day or more for that to be significant. stopping medicine and the knee hurting is NOT withdrawal... it's the medicine working!)
Addiction is falling off the rails and uncontrolled taking:
Not following doctors orders
Getting them from the street/friends/buying/multiple doctors and lying about it.
Taking them just for fun
90 to over 95% of patients on them all the time are NOT addicts.
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What Are The Long Term Effects Of Hydrocodone After Knee Replacement?

About what you ve seen. The hydrocodone has little/no effect on vital organs. Usually it also contains tylenol which in overdose can be damaging to the liver (takes the equivalent of FOUR extrastrength tylenol 4000 mg At One Time to be possibly toxic. We ve all taken much more than that amount over our lifetime.. it has to be an overdose). Likewise death from hydrocodone has to be an overdose and that would have to be more than 5 tablets in one handfill at a very minimum (and at that level likely requires a lot of alcohol or other sedatives to be fatal). And.... Tolerance....getting used to the medicine and not having it work as well (NOT equivalent to addiction). Withdrawal... diarrhea/sweats/shakes with stopping suddenly (likely requires 100 mg a day or more for that to be significant. stopping medicine and the knee hurting is NOT withdrawal... it s the medicine working!) Addiction is falling off the rails and uncontrolled taking: Not following doctors orders Getting them from the street/friends/buying/multiple doctors and lying about it. Taking them just for fun 90 to over 95% of patients on them all the time are NOT addicts.