Hi, my wife was on depo for quite a while- about 10 years. She now has an IUD, and she s been off the shot for about 2 years. She s been experiencing a lot of back pain (she s been seeing a chiropractor) and occasional numbness in her extremities. She has also developed a problem with uncontrollable shaking in her hands and arms, although that comes and goes. My question is, can this be related to some kind of long term side effect of depo? I ve been doing a lot of research online, but I haven t found any definitive answers. (she is scheduled for an MRI this week- they ve already done a cat scan on her brain, but nothing was found)