Hi, You suffer from psoriasis and you are taking methotraxate. Methotraxate improved and controlled your disease. It is a wonderful drug. But, it can cause some side effects like any drug. So, you should be aware of the side effects of methotraxate. Methotrexate may cause side effects...like dizziness,drowsiness, headache, swollen tender gums,decreased appetite,reddened eyes,hair loss..etc. you may have hair loss after taking methotraxate. Some side effects can be serious like...blurred vision or sudden loss of vision, seizures,confusion,weakness or difficulty moving one or both sides of the body, loss of consciousness..etc Methotrexate is usually taken once or twice per week and not every day. You must use the correct dose for your condition. Some people have died after taking methotrexate every day by accident. It should not be taken by pregnant or breast-feeding ladies. Methotrexate can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Methotrexate can cause serious or life-threatening side effects on your liver, lungs, or kidneys. So..you must take it under supervision of dermatologist. I hope you got my answer. Thanks. Dr. Ilyas Patel MD