Hi, I do not advise long term use of Rebeloc (Rabeprozole 40mg further, as i t is indicated for a short duration. has following side effects: In clinical trials the most common side effect assessed as possibly or probably related to AcipHex was headache in 2.4% of patients vs 1.6% taking placebo. diarrhea vomiting nausea abdominal pains constipation meteorism dry mouth increased or decreased appetite asthenia headache anxiety sleeplessness vertigo thrombocytopenia granulocytopenia leukocytopenia skin eruption erythema myalgia arthralgia muscle or bone pain Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GERD); maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD; treatment of daytime and nighttime heartburn and other symptoms associated with GERD; long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.