Hello, I have studied your case with diligence. Side effects of prednisolone Aggression ,agitation ,anxiety ,blurred vision ,decrease in the amount of urine ,dizziness ,or irregular heartbeat or pulse ,headache ,irritability ,mental depression ,mood changes ,nervousness ,noisy, rattling breathing Numbness or tingling in the arms or legs, pounding in the ears, shortness of breath Swelling of the fingers, hands, feet, or lower legs, trouble thinking, speaking, or walking. Troubled breathing at rest, weight gain. Long term side effects of methotrexate Liver damage (not reversible). Lung inflammation or damage. The use of folate supplements (folic and folinic acid) often are given with methotrexate. These are B vitamins and can decrease side effects during methotrexate treatment. Hope this answers your query. If you have additional questions or follow up queries then please do not hesitate in writing to us. I will be happy to answer your queries. Wishing you good health. Take care