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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Can Be The Cause For Low B-cell Level?

” A patient was considered to have B- cell deficiency because serum levels of IgE and IgD were low compared to levels of IgG & IgM. There were low levels of IL- 2, 4, 6 that leads to the cytotoxic CMI leading to low levels of B-Cells”. WHAT IS WRONG WITH THIS QUESTION?
Mon, 1 Jun 2015
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Pathologist and Microbiologist,  's  Response
Hi I did review your concern.
Cytotoxic CMI is caused by CD8+ T cells and not B cells. They cause HMI(humoral or antibody mediated immunity).CD4+ T cells play a bridging role in between these 2 types of Immunity.
Low B cells can be caused by viral infections or primary humoral immunodeficiency disorder and they have obscure causes, mostly genetic in nature.

The treatment involves taking certain precautionary measures as bacterial infection commonly occur with B cell deficiency and taking prophylactic antibiotics and Intravenous immunoglobulins at regular intervals.

I hope this helps
Wish you all the best.
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What Can Be The Cause For Low B-cell Level?

Hi I did review your concern. Cytotoxic CMI is caused by CD8+ T cells and not B cells. They cause HMI(humoral or antibody mediated immunity).CD4+ T cells play a bridging role in between these 2 types of Immunity. Low B cells can be caused by viral infections or primary humoral immunodeficiency disorder and they have obscure causes, mostly genetic in nature. The treatment involves taking certain precautionary measures as bacterial infection commonly occur with B cell deficiency and taking prophylactic antibiotics and Intravenous immunoglobulins at regular intervals. I hope this helps Wish you all the best. Thank you for using healthcare magic.