Thank you for your query. I m sorry that you are going through this. There should be something we can do to help. Based on your symptoms, I would like to to a detailed medical history : -Your age, previous medical conditions, all symptoms & signs with onset, duration, frequency, aggravating/relieving factors. -family medical history - what blood investigations were done with their results, any imaging procedures (xray, ultrasound, CT scan) with reports. -your personal habits :diet, bowel movements I would like to primarily rule out Zoloft as the cause for your abdominal pain & feeling of frustration. If the symptoms started (other than depression) before taking meds I would do the following Although depression & anxiety are psychological symptoms, systemic problem can manifest as anxiety or depression. I would do a basic : :cardiac (Electro & echocardiogram), : respiratory (chest Xray), :gastrointestinal (ultrasound abdomen, stool routine), :urinary (urine routine), :blood (complete blood count, Esr, peripheral smear, clotting profile, urea, creatinine, lipid profile, liver function tests) - rule out sickle cell disease, for instance. :neuromusculoskeletal exam (physical exam) :ENT(ear/nose /throat) exam (rule out ear infection/pathology) Based on this and your clinical exam findings, I may decide to additionally do a colonoscopy, endoscopy. This list may seem extensive but it is necessary to figure out what is going on & treat accordingly. Your symptoms could be all be linked (side effects of medicines) or may represent different problems I urge you to see a doctor and do not stop/alter/add medication regimen by yourself. Express your concern that it should be drug related and ask for safe alternatives. Hope this helps. Wish you good health & get back to us for further queries