Hi. Thanks for your query. Noted the history about your Mother and understood your concerns. Hypertension and diabetes can be well controlled by diet control and exercises, she should walk in the morning and continue with low salt. The main reason to have acidity in the middle of night is the stomach becomes empty hence the acidity is suffered more by such patients, particularly those who have more stress and/or anxiety, which in itself is the cause of diabetes and hypertension. I would advise her to take a PPI like Omeprazole and Ranitidine twice daily. Antacids when on empty stomach. Domperidone to avoid the reflux which usually is the cause of midnight pain. If not sorted out with these medications then obviously an upper GI endoscopy and further management.