hello I reported an anaphylaxis reaction to deplin. I have been diagnosed with homozygous mthfr c667t. At the time, I had psoriasis, shaking hands, poor eyesight and decreasing ability to think and remember. So I wonder if I not being able to use folate in food is related to my reaction. About 3 weeks after taking the deplin, I was given an injection of cyanocobalamin and right away I developed anaphylaxis. I m curious what functional level of methylation could do this. It s so odd to wind up in the ER after taking such common meds. Any ideas?