I have been suffering from constipation and indigestion for the past 3.5 years. Initially it was mainly constipation, but now it has morphed into a complete lack of appetite, weakness along with intractable constipation. I take Naturolax every night, but even after that I need to go to the bathroom at least 5-6 times to feel empty. Many days even that is not enough. I have constant tenesmus throughout the day, no appetite and am chronically weak and lethargic. I have had multiple scopies (both endo and colono) with segmental biopsies, but nothing has been found out. The only diagnosis that I have got from the doctors is one of IBS. But I am sure there is something else to this. I am slowly losing the will to live. Please help me!!