Hi Thanks for posting your query on HCM. I appreciate your concern for the darkening of the skin and the pimples while taking anti TB medications. The side effects involving the skin like rash, itching, orange-red discoloration of the saliva (and other body fluids like tears, sputum, vaginal secretions, etc) are produced by Rifampicin (an important and effective Anti-TB drug). This discoloration is actually harmless and reversible after discontinuing the treatment. However it appears that you have dark pigmentation (hyperpigmentation) on the skin as well as on the nipples. This could have been caused by some other problem like some hormonal imbalance. I advice you to kindly consult your treating doctor or a dermatologist for proper evaluation and to rule out adrenal insufficiency (decreased adrenal hormones) that might result in hyperpigmentation of the skin including the palm creases. Hope this answers your query. Kindly rate this answer, if you are convinced.