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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Darkening Of Skin And Pimples When Suffering From TB?

hi doctor...am 35 years old..now my weight is 47 kg ..my height is 163 cms..am a tb patient..disease started in november last year...doctor asked me to take medicine for 1 year..am taking Rcin 300 and combunex...before taking medicinesmy weight was 43..my problem is now my skin getting darker day by day and pimples also disturbing me...every month i am affected with fever...pls advise...
Mon, 11 May 2015
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General & Family Physician,  's  Response
Hi
Thanks for posting your query on HCM.
I appreciate your concern for the darkening of the skin and the pimples while taking anti TB medications.

The side effects involving the skin like rash, itching, orange-red discoloration of the saliva (and other body fluids like tears, sputum, vaginal secretions, etc) are produced by Rifampicin (an important and effective Anti-TB drug).
This discoloration is actually harmless and reversible after discontinuing the treatment.

However it appears that you have dark pigmentation (hyperpigmentation) on the skin as well as on the nipples. This could have been caused by some other problem like some hormonal imbalance.

I advice you to kindly consult your treating doctor or a dermatologist for proper evaluation and to rule out adrenal insufficiency (decreased adrenal hormones) that might result in hyperpigmentation of the skin including the palm creases.

Hope this answers your query.

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What Causes Darkening Of Skin And Pimples When Suffering From TB?

Hi Thanks for posting your query on HCM. I appreciate your concern for the darkening of the skin and the pimples while taking anti TB medications. The side effects involving the skin like rash, itching, orange-red discoloration of the saliva (and other body fluids like tears, sputum, vaginal secretions, etc) are produced by Rifampicin (an important and effective Anti-TB drug). This discoloration is actually harmless and reversible after discontinuing the treatment. However it appears that you have dark pigmentation (hyperpigmentation) on the skin as well as on the nipples. This could have been caused by some other problem like some hormonal imbalance. I advice you to kindly consult your treating doctor or a dermatologist for proper evaluation and to rule out adrenal insufficiency (decreased adrenal hormones) that might result in hyperpigmentation of the skin including the palm creases. Hope this answers your query. Kindly rate this answer, if you are convinced.