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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Elevated ALT Levels?

Hi. I have had elevated ALT for the past 2 months (the levels seems to fluctuate a lot, between 120 and 330- had around 7 blood tests done). Ultrasound and ct scan have not shown anything. I am also experiencing vertigo. My doctor is sending me for MR scan and if that does not show anything, they will do a liver biopsy. I started to have symptoms 2 weeks after coming back form holidays in Europe.I also sometimes have a slight fever in the evenings (37.3 C) have Any advice please? Could it be Lyme disease or something similar?
Mon, 11 Aug 2014
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Pathologist and Microbiologist 's  Response
Hi,
Thanks for asking.
Based on your clinical history and query, my opinion is as follows:
1. ALT is specific for liver and any elevation indicates ongoing liver injury.
2. As ultrasound and CT scan are negative, a biopsy is essential, if possible to identify any pathology.
3. Evaluation of medications also needs to be done to rule out hepatic injury due to drugs.
4. Specific serology is essential to evaluate further disease. Culture of blood or serology is necessary to diagnose Lyme disease.

Hope it helps.
Any further queries, happy to help again.
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What Causes Elevated ALT Levels?

Hi, Thanks for asking. Based on your clinical history and query, my opinion is as follows: 1. ALT is specific for liver and any elevation indicates ongoing liver injury. 2. As ultrasound and CT scan are negative, a biopsy is essential, if possible to identify any pathology. 3. Evaluation of medications also needs to be done to rule out hepatic injury due to drugs. 4. Specific serology is essential to evaluate further disease. Culture of blood or serology is necessary to diagnose Lyme disease. Hope it helps. Any further queries, happy to help again.