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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Elevated Alpha Anti-chymotrypsin?

I had a stool GI panel and one of the biggest concerns I have is the alpha anti-chymotrypsin came back as 292 which is way off the charts. Normal is 180. Should I be in the hospital or how should this be treated? I started taking Cephalexin (500 mg) and also am starting on probiotics and digestive enzymes. Am very uncomfortable, lots of bloating and gas and a sensitive, sore colon.
Mon, 1 Sep 2014
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Pathologist and Microbiologist 's  Response
Hi!
welcome to HCM!
Stool alpha 1-antichymotrypsin levels increase at times of GI inflammation, particularly of the small intestine. High stool levels of this protein are typically associated with inflammatory bowel diseases, especially Crohn's Disease (likely due to its tendency to affect the small intestine), but it can also be elevated in acute intestinal inflammation secondary to other causes.You can seek medical help if uncomfortable but just the rise of this enzyme is not a medical emergency.
hope this helps!
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What Causes Elevated Alpha Anti-chymotrypsin?

Hi! welcome to HCM! Stool alpha 1-antichymotrypsin levels increase at times of GI inflammation, particularly of the small intestine. High stool levels of this protein are typically associated with inflammatory bowel diseases, especially Crohn s Disease (likely due to its tendency to affect the small intestine), but it can also be elevated in acute intestinal inflammation secondary to other causes.You can seek medical help if uncomfortable but just the rise of this enzyme is not a medical emergency. hope this helps!