I take clonidine 0.2 along with lisinopril 20mg twice a day and bisoprolol 25mg once. This combination seems to work. I recently had an event where blood pressure spiked 188/107. went to the hospital and did it all. stress test,heart cath and echo. all was said to be ok, however they had to resort to a nitro drip to get my pressure down after cath. they tried various meds to keep it down. My wife gave my regular meds to me and it came down. My doctor is concerned about the side effects of this comb. As for me my complaint is ED. I take 5 mg of cialas with my meds daily, I have had no problems resulting from this. If anything it helps. Very little change in pressure... I ve checked. I do however have had some of the side effects from clonidine. Mostly fatigue. and the ed with the mix of lisinipril and clonidine. By the way I m 67, still work as a contractor. With the exception of HBP Im completely healthy. Are there any other med comb. to discuss with my doctor. I ve tried hydralazine to eliminate clonidine and lisinipril. Didn t work. Any information you could share with me AND my doctor (I would never go it alone) Thank you, and have a Blessed Day J. Paul