My Mother is 92 and has a pacemaker for over 30 years. Since having her last pacemaker surgery in May 2013 she was taken off of baby aspirin which she had been taking for a while and was put on Pradaxa and entered into a 2 year study but she did not do well on this drug and it was changed last December to 2.5 mg of Apixaban 2 times per day. In April my mother had an TIA and her doctor upped the dosage of the Apixaban to 5 mg 2 times per day last week to avoid another stroke. Since the increase my mother is now passing blood in her urine. Is this too much too soon for a 92 year old? would it be better for the increased amount of Apixaban be introduced moderately to allow her body to get use to it?