Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.
Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat
rheumatoid arthritis,
psoriatic arthritis, and
ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (
tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.
Common side effects of Simponi include dizziness, cold symptoms (stuffy nose, sneezing, sore throat), or injection site reactions (redness, itching, pain, or swelling).
According to your history as described in your question there are symptoms of liver damage (including dark urine, persistent nausea/vomiting/loss of appetite, stomach/
abdominal pain, or yellow eyes or skin).
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Narender Kumar