Hi, In addition to nightmares, people with PTSD can manifest a state of hyperarousal, in which the individual is subconsciously “on guard” to protect himself, and as a result feels anxious, has difficulty falling asleep, is irritable, suffers emotional outbursts, or is easily startled. Treating patients with PTSD for sleep disorders has sometimes been heartbreaking. Until the past few decades, people with PTSD were not treated for it, because the condition had not even been described. Today, treatments have evolved and patients can benefit from them. Treatment should be coordinated by an expert in treating PTSD, most often a psychiatrist. The therapies that may be effective are the “talk therapies,” often in concert with medications. Two drugs have been approved by the FDA to treat PTSD: Sertraline (Zoloft®) and Paroxetine (Paxil®). In an exciting development, recent research shows that an “old” drug, Prazosin, originally used to treat high blood pressure, may be effective in reducing the nightmares in PTSD patients. It is believed that norepinephrine may play a role in causing sleep disturbances and nightmares in PTSD, and prazosin reduces the levels of norepinephrine in the brain. As far as beta blockers are concerned. Effectiveness. The researchers have found compelling evidence that taking a beta blocker after having had a heart attack lowers the chances of a repeat heart attack or an early death. These drugs also increase the chances of living longer and better with heart failure. The reviewers found that different beta blockers work better for different conditions. Safety. Beta blockers are generally safe to take. Side effects tend to be annoying, not life-threatening. Cost. Almost all beta blockers are available as low-priced generics. Continue taking them. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Ajeet Singh, General & Family Physician