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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Persistent Fever Inspite Of All Negative Tests?

Hi, I am a 29 year old female and have had persistent fever for about a month now. I was diagnosed with Typhoid (through Widal blood test) around 29th of November and took medication to cure it. Post that, fever has still not subsided, even though I have got a repeat of Widal test (which is now negative), along with several other blood and urine culture tests to rule out other illnesses. These include Dengue, Malaria, Brucella. All have come back negative. Doctors say it is PUO. Any advice on what it could be? I have finished antibiotic course of Oflin 400mg for 7 seven days, post which I got ESR test done, it is 93mm/ hour and late evening fever of about 99.8 degrees every evening.
Medical history - I had pulmonary cox at the age of 17, and was treated for it at the time. Now, to diagnose if I have TB again, I got blood PCR test for TB, which came out negative. Mantoux skin test was positive, which I was told could be due to the earlier infection I had as a teenager.
Please suggest what this could be and any further tests?
Tue, 13 Jan 2015
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General & Family Physician,  's  Response
MULTIPLE CAUSE OF FEVER.
FIRST OF ALL RULE OUT TB
GO FOR .
X-RAY CHEST.
ULTRASOUND ABDOMEN.
SPUTUM FOR AFB.
CT CHEST & ABDOMEN.
BLOOD CULTURE.
ANA TEST TO RULE OUT AUTO IMMUNE DISEASES.
MANY A TIMES WE HAVE TO REPEAT ALL TESTS TO SEE PROGRESS OF DISEASE.
BACTERIA MAY BE RESISTANT TO OFLOXACIN.
7 DAYS ANTIBIOTIC IS NOT ENOUGH.
WAIT .YOU WILL BE ALRIGHT.
FEEDBACK TO H C M.
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What Causes Persistent Fever Inspite Of All Negative Tests?

MULTIPLE CAUSE OF FEVER. FIRST OF ALL RULE OUT TB GO FOR . X-RAY CHEST. ULTRASOUND ABDOMEN. SPUTUM FOR AFB. CT CHEST & ABDOMEN. BLOOD CULTURE. ANA TEST TO RULE OUT AUTO IMMUNE DISEASES. MANY A TIMES WE HAVE TO REPEAT ALL TESTS TO SEE PROGRESS OF DISEASE. BACTERIA MAY BE RESISTANT TO OFLOXACIN. 7 DAYS ANTIBIOTIC IS NOT ENOUGH. WAIT .YOU WILL BE ALRIGHT. FEEDBACK TO H C M.