Hello, Thank you for posting on HCM. The condition you have referred to is called urticaria or hives. Its an allergic manifestation of skin, where an allergen leads to release of certain substances from your blood, leading to itchy skin rash and swelling over soft tissues. Exedrin tablet contains acetaminophen ,aspirin and caffeine, out of which aspirin has tendency to cause hives. Moreover, sea foods are notorious for allergic conditions esp. hives. Its proper management requires thorough history, clinical and laboratory work-up. As, you have specifically mentioned proteins you go for specific tests like patch test, food prick test etc. As for treatment part, best would be the avoidance of allergen as far as possible. Try to eliminate possible triggering foods from diet. I would also advise you various anti-histaminics for long duration( atleast 3 months) with or without oral corticosteorids. For non- responding cases there are many other drugs like dapsoe, cyclosporine, montelukast, omalizumab etc which can be used un certain selected cases. Hope this will help you in resolving your query. Thank you Dr Hardik Pitroda