I have reddened dry patches of skin on bottoms of my feet that at times itches even if the areas are torn open. I understand about the release of histamine etc. I am a BSN RN? My doctor is at a loss for a Dx.... Antifungals, cortisone, and anti- itch creams do not work. I have a Hx of IgM mild suppression, hyper elevated IgE, high neutrophils, elevated eosinophils, and depressed lymphocytes.