Hello and welcome to Ask A Doctor services. I have read your query and here is my advise. * As per my clinical experience, there can be various reasons for severe fatigue with muscle ache as - nutritional deficiencies involving iron, vitamins, proteins, trace elements as zinc, magnesium or others - low levels of active thyroid hormones as in hypothyroid status - menopause related ( also usual co existence of hot flashes, mood swings ) Needs a definite evaluation with your physician for look into the matter and best guidelines accordingly. Wish you best health and recovery. Thank you. Regards.