Hello, Atorvastatin may indeed cause fatigue but it s not supposed to do so very frequently. Actually less than 1% of patients taking atorvastatin may be affected. If your symptoms occurred after starting atorvastatin then this could be an explanation. Otherwise you should look elsewhere for the cause. Breast cancer - if active - sounds like a more likely cause for example. A check-up may help to identify other potential factors that may cause tiredness, including anemia, electrolyte disorders, impaired renal indices, etc. Fatty liver disease or high cholesterol cannot possibly cause tiredness. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Panagiotis Zografakis, Internal Medicine Specialist