Crestor (rosuvastatin) is a statin and muscle aches are one of the common side effect. Zetia (ezetimibe) is not a statin and incidence of muscle aches are uncommon with this drug. Cholesterol lowering agent that does not have muscle aches as side effects are bile acid sequestrates like cholestyramine and colesevelam. But they have a higher incidence of gastrointestinal side effects. Other drugs that lower lipids like niacin and fibrates can cause muscle aches. But can be given a trial. If you were my patient, then I would look at vitamin D levels before considering the medication change now. Vitamin D deficiency can also lead to muscle aches and is also a common cause. I hope the above information helps you. Thanks for writing into healthcare magic.