What Causes The Increase In Eosinophil Levels?

1.      Am a 39 yr man who was diagnosed with DVT (left lower limb) following a 10 hr flight in Dec 09. Subsequently, hyper eosinophilia (45-48%) detected in end Dec 09. For DVT, I was on Claxin and thereafter on Warfarin/Sofarin (7.5 mg OD). DVT was detected in ATV, PTV, SFV and Popletial. As on Nov 10 CDFI report, DVT has largely recannalised. 2.     For hyper eosinophilia, I was given a month’s course of Prednisolone. With that course the eosinophil count was down to 5%. However, on stopping it, it went back to 46%. I was also given a course of Veenat (100mg OD x 30 days, Imatimb( or is it Hematin), to rule out F1P1L1 PDGFRA- β (since test is not available). There was no response. As long as am on steroid eosinophil counts are at 5-10 %. On stopping Prednisolone, it goes back to 45-50 %. Course of Hetrazan also given prior Prednisolone-no response. 3.     Jan –Mar 11.     Am presently on low dose steroid (Prednisolone 10 mg OD) and 1000 mg OD Hydroxy urea. Continue to be asymptomatic. 4.      Till now sickle cell, cryoglobulin, Hb electrophorosis, CD 55, 59, F1P1L1 PDGFRA -α tests done. All tests negative. BCR/ABL Assy is 0%. D dimer level 1.39. Homocystine level in Jun 10 was 18.6. Protein S levels -9%, Protein C- 120%, AT III- 59%. Protein S and ATIII are low- am told that these low levels are cause for DVT. In Feb 10 cholesterol 280, triglycerides 140, HDL 49, LDL 207 VADL cholesterol 26. After a short (2 week) on Atorvastatin 20 mg HS. These levels were WNL. In Nov 10 cholesterol 250, triglycerides 140, HDL 42, LDL 139 VADL cholesterol 28. All WNL. PFT, echo, USG abdomen and X ray chest – normal. Presently on Prednisolone 10mg od and warfarin 5 mg od for dvt and 1000 mg hydroxy urea. 5.     In Mar 10, Bone marrow aspriration showed erythryopoesis is normablastic, mycloid series shows increase in eosinophils and eosinophil myclocytes around 10% of ANC. Megakaryocytes adequately represented. Opinion is prominence of eosinophils, no increase in blasts. BM biopsy also indicates eosinophilia. Endoscopy biopsy not done due being on Warfarin.